Written By: Devin Golden
Sarcomatoid Mesothelioma
Sarcomatoid mesothelioma is one of three cell types of mesothelioma. Sarcomatoid mesothelioma is the rarest and most aggressive mesothelioma cell type, as it spreads quickly and can be challenging to treat.
Medically Reviewed By
Karen Ritter, RN BSN
Registered Nurse
Medically Reviewed By
Karen Ritter, RN BSN
Registered Nurse
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Important Facts About Sarcomatoid Mesothelioma
- Sarcomatoid mesothelioma is the rarest mesothelioma diagnosis and has the poorest life expectancy.
- Sarcomatoid cells are mutated epithelial cells caused by irritation from asbestos exposure.
- Due to the rapid growth and spread of sarcomatoid cells, this cell type is often difficult to treat.
What Is Sarcomatoid Mesothelioma?
Sarcomatoid mesothelioma is one of three cell types of the rare cancer malignant mesothelioma. The other two cell types are epithelioid mesothelioma and biphasic mesothelioma. Sarcomatoid mesothelioma is the rarest of the three. It results from mutated mesothelial cells.
Specialists evaluate the cells present in the patient’s body to diagnose the mesothelioma type, which can be primarily sarcomatoid, primarily epithelioid, or a combination of the two (called “biphasic”).
Asbestos exposure is the only cause of mesothelioma. Asbestos fibers get trapped in linings of the body, which leads to irritation and mutation of mesothelial cells. The linings where mesothelioma can form are around the lungs, abdominal cavity and heart.
Sarcomatoid Cell Type
According to a report in Modern Pathology, sarcomatoid mesothelioma tumors form far more often near the lungs (pleural mesothelioma) than the abdominal cavity (peritoneal mesothelioma). A study showed that 98% of sarcomatoid cases are pleural mesothelioma.
This cell type of mesothelioma metastasizes at a rapid pace, meaning tumors spread quickly to surrounding tissues and other parts of the body. Sarcomatoid mesothelioma is the most difficult cell type to treat due to the aggressive nature of this disease, although developing treatments (such as immunotherapy) are leading to improved survival.
Characteristics of Sarcomatoid Mesothelioma Cells
Cell Prevalence
The sarcomatoid mesothelioma cell type accounts for 10% - 20% of mesothelioma cases.
Cell Description
The description of sarcomatoid cells is they are spindle-shaped, long and narrow. They have enlarged, elongated nuclei. These cells can have more than one nucleus and can be hard to distinguish from healthy cells and tissue.
Cell Behavior
Sarcomatoid cells have erratic cell behavior. These cells do not form in regular patterns like epithelioid cells. Instead, they multiply rapidly through soft tissue and are difficult to identify and remove.
What Causes Sarcomatoid Mesothelioma?
Sarcomatoid mesothelioma is caused by epithelial cells turning cancerous and transitioning into sarcomatoid cells.
The human body is made up of four types of cells: epithelial cells, nerve cells, muscle cells and connective tissue cells. Epithelial cells are found in the linings of the lungs, abdomen and heart. The lining of these organs is called the mesothelium.
When asbestos fibers invade these linings, they stick to the mesothelium and irritate the healthy mesothelial cells, causing genetic mutation and tumor formation. This is how mesothelioma forms. The epithelial cells affected by asbestos can transform into sarcomatoid cells.
Epithelial cells line the thin membrane around the lungs, inside the abdominal cavity and around the heart.
Epithelial cells can mutate and transform into cancerous mesothelioma sarcomatoid cells. This change is called the epithelial-to-mesenchymal transition (EMT).
Mesenchymal cells are usually part of the body’s connective tissue (such as bones and cartilage). When they become cancerous, they are called “sarcomas.”
Sarcomatoid Mesothelioma Symptoms
Sarcomatoid mesothelioma symptoms include shortness of breath, chest or back pain, coughing, difficulty swallowing and nausea.
Symptoms vary based on where the cancer forms, such as in the lining of the lungs (pleural mesothelioma) or in the lining of the abdominal cavity (peritoneal mesothelioma).
Pleural mesothelioma symptoms include:
- Shortness of breath
- Chest or back pain
- Coughing
- Difficulty swallowing
- Pleural effusions (fluid buildup)
Peritoneal mesothelioma symptoms include:
- Abdominal pain
- Nausea
- Vomiting
- Constipation
- Abdominal distention (from accumulation of fluid in the abdomen)
Connect with
a Peritoneal Mesothelioma Specialist
Sarcomatoid Mesothelioma Diagnosis
Receiving a sarcomatoid mesothelioma diagnosis begins with seeing a doctor for imaging tests and then having a biopsy.
The sarcomatoid cell type is often difficult to identify and accurately diagnose. The rare nature of this cell type can leave physicians with a lack of knowledge and experience in providing an accurate diagnosis.
Another challenge in diagnosing sarcomatoid mesothelioma is the similarity between healthy cells and cancerous cells. Sarcomatoid cells can appear similar to benign tissue, which makes it difficult to identify. Due to the infrequency of diagnosing this mesothelioma cell type, doctors are often unfamiliar with the sarcomatoid cell type and the cell appearance.
According to a study published in the National Library of Medicine, sarcomatoid mesothelioma has been shown to have the most inconsistent expression of cytokeratin and calretinin, two common tumor markers. This is one of the obstacles specialists may face during histoimmunochemical testing as they attempt to identify the cell presence and determine a proper diagnosis.
Immunohistochemistry for Sarcomatoid Mesothelioma
If the biopsy is adequate, pathologists will use immunohistochemistry to accurately identify the cell type. Immunohistochemistry involves staining antibodies and using them to check for antigens (markers). The antibodies bind to the antigens and the stain (or dye) will be activated. This identifies the antigen and helps specialists determine the cell type of the patient’s mesothelioma.
Immunohistochemical markers for sarcomatoid mesothelioma include:
- Podoplanin (D2-40)
- Pancytokeratin
- Calretinin
- GLUT1
Second Opinions
Many oncologists and surgeons do not have the experience required to understand the complexity of mesothelioma. This cancer is quite rare and requires a deep understanding to identify, diagnose, and treat. Patients diagnosed with mesothelioma, especially those with rare cell types like sarcomatoid, should seek a second opinion from a doctor specializing in mesothelioma.
Mesothelioma specialists dedicate their careers to better understanding mesothelioma and how to effectively treat it. Finding a mesothelioma specialist to analyze diagnostic tests and determine an effective treatment plan can make a difference in having a positive outcome.
Getting a second opinion from a mesothelioma specialist can significantly improve your chances of survival. Oncologists and surgeons do not typically have the experience needed to devise the perfect treatment plan, as some mesothelioma treatment methods are emerging and not yet FDA-approved.
Due to the rarity of mesothelioma, it is sometimes necessary to get a pathology lab to provide a second opinion to obtain a definitive diagnosis. For instance, Johns Hopkins Medicine has a specialized pathology lab dedicated to providing second opinions for diagnostic purposes.
Specialists can confirm the best treatment plan for each individual patient by analyzing pathology reports. Not all cancer is the same, and not all treatments are effective for all patients. Receiving a second opinion from a qualified specialist is crucial in fighting mesothelioma.
Sarcomatoid Mesothelioma Treatment Options
Sarcomatoid mesothelioma treatment options include surgery, chemotherapy, immunotherapy and radiation therapy.
Sarcomatoid mesothelioma is the rarest cell type of mesothelioma but also the most aggressive. Treatment options are often limited as tumors with this mesothelioma cell type have a poor response to typical treatment methods.
Surgery can be ineffective for patients with sarcomatoid mesothelioma. The scattered growth pattern of sarcomatoid cells makes removal difficult. These types of cells don’t clump together like epithelioid mesothelioma cells do, which creates strict criteria for surgery eligibility.
Despite hesitation from doctors, there are cases of surgery working for people with sarcomatoid mesothelioma. A case report published in 2024 features a 63-year-old man with sarcomatoid pleural mesothelioma. He received lung-removal surgery and has been cancer-free for 10 years since the operation.
Sarcomatoid Mesothelioma Surgery
Sarcomatoid mesothelioma surgery can remove tumors from the patient’s body and extend their survival. Patients with pleural mesothelioma have two surgical options (if eligible) to remove tumors from the chest cavity: extrapleural pneumonectomy and pleurectomy with decortication. Patients with pleural mesothelioma have two surgical options (if eligible) to remove tumors from the chest cavity: extrapleural pneumonectomy and pleurectomy with decortication.
Extrapleural pneumonectomy (EPP) involves the removal of the affected inner pleural lining attached to the lung (visceral pleura), the outer pleural lining attached to the chest wall (parietal pleura), the entire diseased lung, and may include part of the diaphragm and the lining around the heart (pericardium).
Pleurectomy with decortication (P/D) involves the removal of the affected inner pleural lining of the lung (visceral pleura) and outer pleural lining (parietal pleura). An extended version of P/D, sometimes called a “radical pleurectomy”, may also include the removal of part or all of the diaphragm and pericardium, if diseased tissue is present.
Cytoreduction with heated intraperitoneal chemotherapy (HIPEC) is the surgical option to treat sarcomatoid peritoneal mesothelioma. It is an aggressive surgery beginning with cytoreduction (debulking), which removes all visible tumors in the abdomen. The surgeon will then remove the peritoneum (lining inside the abdominal cavity).
Many times it is necessary to remove part of the intestines or other affected abdominal organs. Once all the visible tumors are removed, the doctor will administer a heated intraperitoneal chemotherapy solution directly into the abdominal cavity.
Chemotherapy, Immunotherapy, Radiation and Emerging Sarcomatoid Mesothelioma Treatment Methods
Treatment methods are often limited for this cell type due to the rarity and aggressive nature of the disease. However, chemotherapy, immunotherapy and radiation are commonly recommended, either when surgery isn’t possible or in addition to surgery.
With many mesothelioma clinical trials currently underway, researchers hope to develop new treatments for sarcomatoid mesothelioma through oncolytic virus therapy, gene therapy and other emerging treatments. These forms of care have the potential to increase survival rates in the future.
Some clinical trials will exclude cases of sarcomatoid mesothelioma due to the difficulty of treating this cell type. However, many experts in cancer treatment believe this exclusion is faulty, and many clinical trials welcome patients with this cell type.
According to a published report in the Journal of Thoracic Oncology, two medical groups state that a sarcomatoid mesothelioma diagnosis should not exclude a patient from receiving chemotherapy or enrolling in clinical trials involving surgery, immunotherapy or a new type of treatment.
Chemotherapy is a first-line treatment for mesothelioma. The United States Food and Drug Administration has approved two chemotherapy drugs — pemetrexed and cisplatin — for mesothelioma.
Immunotherapy is an emerging treatment option and becoming more accepted for the treatment of mesothelioma. The FDA has approved three immunotherapy drugs (Opdivo, Yervoy and Keytruda) for mesothelioma treatment.
Radiation therapy is often used as a second-line treatment for sarcomatoid pleural mesothelioma. It is not used for other types of mesothelioma due to the increased risk of damaging nearby vital organs. Radiation beams can damage the organs and lead to further health issues.
Multimodal treatment is often an effective approach for mesothelioma as it combines multiple therapies or treatment methods to improve effectiveness. It is common for specialists to recommend combining surgery with chemotherapy or chemotherapy with radiation in some cases.
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a Mesothelioma Cancer Center
Subtypes of Sarcomatoid Mesothelioma
There are three rare subtypes of sarcomatoid mesothelioma: transitional mesothelioma; lymphohistiocytoid mesothelioma; and desmoplastic mesothelioma. The subtype of the cancer can affect treatment. Certain subtypes are less responsive to traditional treatments and add a layer of complexity to the diagnostic process.
The three subtypes of sarcomatoid mesothelioma are:
- Transitional mesothelioma
- Lymphohistiocytoid mesothelioma
- Desmoplastic mesothelioma
Prognosis for Sarcomatoid Mesothelioma
The average prognosis for sarcomatoid mesothelioma is approximately less than one year. This is a shorter prognosis than the two other cell types: epithelioid and sarcomatoid mesothelioma.
According to a 2018 study published in Clinical Lung Cancer, the median survival rate for patients who do not undergo treatment is less than six months.
If the disease is diagnosed at an early stage, and if the patient meets the surgical and treatment criteria, then their postoperative life expectancy increases to an average of 11.2 months.
The location of the mesothelioma also affects prognosis. In one study:
People with pleural mesothelioma and sarcomatoid cell type survived for an average of 8 months
People with peritoneal mesothelioma and sarcomatoid cell type survived for approximately 13 months on average
There are people diagnosed with sarcomatoid mesothelioma who have significantly outlived their life expectancy. These survival stories are largely thanks to early diagnosis and aggressive treatment.
Learn how survivors beat the odds in our free Mesothelioma Survivor’s Guide.
Support Options for Patients With Sarcomatoid Mesothelioma
There are support options for people with sarcomatoid mesothelioma. These support resources can provide emotional and financial help to patients and their families.
Mesothelioma is a devastating disease and can take a toll on a patient’s physical and mental health. It’s important to maintain your health and overall well-being during treatment and recovery from treatment. There are many resources available to patients with mesothelioma, as well as their loved ones and caregivers.
To learn more about mesothelioma support options, connect with nurse navigator Karen Ritter. She can connect you with local and virtual support groups, or provide you with helpful resources.
Frequently Asked Questions About Sarcomatoid Mesothelioma
What does sarcomatoid mesothelioma look like?
Sarcomatoid mesothelioma looks spindle-shaped, long and narrow. They don’t have a defined structure but rather an elongated and inconsistent shape. They also can have multiple nuclei, don’t show any clear borders, and don’t always develop in clear patterns or bunches.
How is sarcomatoid mesothelioma treated?
Sarcomatoid mesothelioma is treated with surgery, chemotherapy, immunotherapy and radiation therapy. Most patients receive chemotherapy or immunotherapy because surgery is often challenging due to the way sarcomatoid cells spread and multiply. Mesothelioma Guide’s team can help you or a loved one find a clinical trial to fit your needs.
How common is sarcomatoid mesothelioma?
Sarcomatoid mesothelioma is diagnosed in at most 20% of mesothelioma cases. Mesothelioma is only diagnosed in approximately 2,500 people in the U.S. each year, so sarcomatoid mesothelioma only occurs in a few hundred cases each year.
What is the average survival time for people With sarcomatoid mesothelioma?
The average survival time for people with sarcomatoid mesothelioma is less than one year. This cell type of mesothelioma has the poorest average prognosis of the three cell types. However, there are stories of patients with sarcomatoid mesothelioma far surpassing their life expectancy and living for five or more years.
Sources & Author
- About Malignant Mesothelioma. American Cancer Society. Retrieved from: https://www.cancer.org/content/dam/CRC/PDF/Public/8733.00.pdf. Accessed: 10/01/19.
- What Is a Soft Tissue Sarcoma? American Cancer Society. Retrieved from: https://www.cancer.org/cancer/soft-tissue-sarcoma/about/soft-tissue-sarcoma.html. Accessed: 04/17/19.
- Malignant Pleural Mesothelioma. Edited by Kenneth O’Byrne and Valerie Rusch. Oxford University Press. 2006.
- Signs and Symptoms of Mesothelioma. American Cancer Society. Retrieved from: https://www.cancer.org/cancer/malignant-mesothelioma/detection-diagnosis-staging/signs-symptoms.html. Accessed: 10/04/19.
- Guidelines for Pathologic Diagnosis of Malignant Mesothelioma. International Mesothelioma Interest Group. Retrieved from: https://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2017-0124-RA. Accessed: 10/04/19.
- EURACAN/IASLC proposals for updating the histologic classification of pleural mesothelioma: towards a more multidisciplinary approach. Journal of Thoracic Oncology. Retrieved from: https://www.jto.org/article/S1556-0864(19)33232-0/pdf. Accessed: 10/11/19.
- Life Expectancy in Pleural and Peritoneal Mesothelioma. Lung Cancer International. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292397/. Accessed: 10/11/19.
- The basics of epithelial-mesenchymal transition. U.S. National Library of Medicine. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689101/. Accessed: 04/17/19.
- Survival by Histologic Subtype of Malignant Pleural Mesothelioma and the Impact of Surgical Resection on Overall Survival. Clinical Lung Cancer. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/30224273. Accessed: 10/11/19.
- Pleura Mesothelial tumors Mesothelioma – sarcomatoid. Pathology Outlines. Retrieved from: http://www.pathologyoutlines.com/topic/pleuramesotheliomasarcomatoid.html. Accessed: 01/04/19.
- Sarcomatoid mesothelioma: a clinical-pathological correlation of 326 cases. Modern Pathology. Retrieved from: https://www.nature.com/articles/modpathol2009180. Accessed: 08/08/2023.
- Sarcomatoid Mesothelioma: Unusual Findings and Literature Review. National Library of Medicine. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675762/. Accessed: 08/09/2023.
- The Immunohistochemical Characterization of Sarcomatoid Malignant Mesothelioma of the Pleura. National Library of Medicine. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180102/. Accessed: 08/11/2023.
- Sarcomatoid malignant pleural mesothelioma: a case of long-term recurrence-free survival following curative intent surgery alone. Surgical Case Reports. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/38819480/. Accessed: 06/04/2024.
